MECHANISM OF ACTION

Vitamin D3 (cholecalciferol) belongs to the group of liposoluble vitamins with significant fisiological effects. The regulation of its metabolism is complex and involves calcium, phosphate and hormones, the most important of which is PTH (parathyroid hormone). The two most important mechanisms by which vitamin D maintains normal calcium and phosphate concentrations are facilitating the resorption of calcium and phosphate from the intestine and accelerating their mobilization from bone. In the absence of vitamin D, the resorption of calcium and phosphate from the digestive tract is significantly reduced. As a result, a larger amount of PTH is secreted, which mobilizes calcium from the bones. This leads to bone demineralization, which can be manifested by rickets in children, or osteomalacia and osteoporosis in adults.
The role of vitamin D is to prevent demineralization and has a preventive effect on these processes. In addition to the effects on bone health, vitamin D shows a beneficial effect in autoimmune, malignant, cardiovascular and other diseases in which vitamin D replacement is necessary.
Vitamin K2 (menaquinone) is synthesized by bacteria in intestines, and belongs to the group of liposoluble vitamins. Relatively recent studies have shown that vitamin K2 (menaquinone) participates in the modulation of osteocalcin and the maintenance of bone health, and can be considered useful in the prevention of osteoporosis. In addition to its effects on bone health, vitamin K2 has a beneficial effect on cardiovascular, malignant and other diseases, especially in combination with vitamin D3.